Efficacy and Effects of Urea Cream

The main active ingredient in urea cream is urea. Urea cream has moisturizing properties. For individuals with dry skin, topical application of urea cream can provide symptomatic relief. Its mechanism of action involves dissolving keratin in the stratum corneum, thereby softening the skin and reducing the risk of cracking. Clinically, it is commonly used to treat conditions such as eczema, psoriasis, and keratosis pilaris. In rare cases, patients may experience local adverse reactions—including burning sensation, pruritus, or erythema and swelling—upon application; if such symptoms occur, use should be discontinued.