What causes fever during radiation therapy?

Oct 21, 2022 Source: Cainiu Health
Disease description:

After Grandma got sick, she underwent radiotherapy at the hospital. She has had a fever for the past two days. What causes fever during radiotherapy?

Doctor's answer (1)
Dr. Peng Xiaodong
Radiation-induced fever may result from drug-induced irritation to the body, or it may occur because the patient has relatively weak immune function, which further declines after radiotherapy, making them susceptible to bacterial, viral, or fungal infections. Additionally, when radiation reaches a certain dose, it often causes tumor tissue necrosis. As the body absorbs these necrotic tissues, inflammatory factors may be released and stimulate the body's temperature regulation center, leading to fever.