Where should toothpaste be applied to cause a fever?

Applying toothpaste to any part of the body will not cause fever. Toothpaste, a daily necessity for cleaning teeth, mainly contains abrasives, thickeners, and surfactants. These components do not have biological effects that can cause fever in the human body. Fever is typically triggered when exogenous pyrogens, such as pathogens, viruses, or bacteria, enter the body and stimulate the production of endogenous pyrogens, which then act on the thermoregulatory center, causing the body's temperature set point to rise above the normal range. Toothpaste is unrelated to this process, and therefore, applying toothpaste on any part of the body will not induce fever. If fever occurs, other possible causes such as infections or immune system diseases should be considered, and timely medical consultation should be sought for diagnosis and treatment.