Does DHEA cause weight gain as a side effect?

DHEA’s side effects generally do not cause weight gain; however, individual absorption varies, so this is not absolute. Weight gain during DHEA use may occur if the individual consumes calorie-dense or obesity-promoting foods and engages in insufficient physical activity. Additionally, prolonged use of DHEA may lead to virilization in women (e.g., deepening voice, increased facial hair, acne); therefore, it should not be taken indiscriminately.