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Normal value of B-type natriuretic peptide

Sep 13, 2022 Source: Cainiu Health
Dr. Pan Yongyuan
Introduction
The normal range for N-terminal pro-B-type natriuretic peptide (NT-proBNP) should not exceed 125 pg/mL. However, this value increases with age, and for individuals over 75 years old, the normal range should not exceed 450 pg/mL. NT-proBNP is a molecule produced alongside B-type natriuretic peptide (BNP). During BNP synthesis, the precursor molecule—proBNP—is formed first, which is then cleaved into two parts.

Natriuretic peptide, also known as B-type natriuretic peptide (BNP), is an active hormone secreted by ventricular myocardium. So, what is the normal value for B-type brain natriuretic peptide?

Normal Value of B-Type Brain Natriuretic Peptide

The normal range for N-terminal pro-B-type natriuretic peptide (NT-proBNP) should not exceed 125 pg/mL. However, this value increases with age, and for individuals over 75 years old, the normal range should not exceed 450 pg/mL. NT-proBNP is a substance produced in equimolar amounts along with BNP during its synthesis. During BNP production, the precursor—proBNP—is formed first, which is then cleaved into two parts: BNP and NT-proBNP.

Natriuretic peptides are biologically active hormones that promote diuresis and natriuresis and dilate blood vessels, thereby reducing both preload and afterload on the heart and providing cardioprotective effects. In patients with heart failure, BNP levels increase as a compensatory mechanism, and similarly, the N-terminal fragment of its precursor (NT-proBNP) also rises compensatorily. Therefore, NT-proBNP serves as an important biomarker for diagnosing heart failure and assessing patient prognosis. Elevated levels may indicate the presence of heart failure, necessitating further diagnosis and treatment.

Clinically, NT-proBNP is widely used in the diagnosis and prognostic evaluation of heart failure. It is extensively distributed in tissues such as the heart, lungs, and brain, with the highest concentration found in the heart. Within the heart, B-type natriuretic peptide is primarily present in the left and right atria. When heart failure occurs, changes in ventricular volume load and wall tension stimulate the excessive secretion of BNP, leading to natriuresis, diuresis, blood pressure regulation, and vasodilation, ultimately helping to reduce cardiac workload. We hope this answer has been helpful to you. Wishing you good health and happiness!

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