HPV negative in late-stage cervical cancer
Sep 13, 2022
Source: Cainiu Health
Dr. Lv Aiming
Introduction
Current research on HPV has reached a conclusion: persistent presence of HPV in the human body for 8 to 10 years may lead to cervical cancer. Among cervical cancer patients, 98% to 99% have been infected with HPV, but not all cases (not 100%) are caused by HPV infection. It is possible, though extremely rare, to develop cervical cancer even with negative HPV status. When cervical cancer progresses to an advanced stage, radiotherapy and chemotherapy are available treatment options.
Since the cervix in women lacks pain-sensing nerves, cervical cancer is usually diagnosed at an intermediate or advanced stage. Therefore, regular HPV testing is recommended. But if HPV test results are negative, can one still have late-stage cervical cancer?
Can late-stage cervical cancer occur with a negative HPV test?
Current research has confirmed that persistent HPV infection in the body over 8 to 10 years may lead to cervical cancer. Among cervical cancer patients, 98% to 99% have had prior HPV infection, although not all cases are caused entirely by HPV.
It is possible to develop cervical cancer even with a negative HPV test, though this is extremely rare. In advanced stages of cervical cancer, when the disease has progressed too far for surgical intervention, radiation therapy and chemotherapy remain viable treatment options. Particularly radiotherapy, which is highly effective for cervical cancer and can achieve outcomes comparable to surgery.
After diagnosis, it's important to actively follow your doctor’s guidance regarding radiotherapy and chemotherapy, along with regular follow-up examinations to monitor recovery. For the first three years after treatment,复查 should be done every three months; from years 3 to 5, every six months; and annually after five years. We hope this answer helps you. Wishing you good health and happiness!
