What is the first-line drug for treating anaphylactic shock?
Jun 03, 2019
Source: Cainiu Health
Dr. Zhang Min
Introduction
What is the first-line drug for treating anaphylactic shock?
The initial management of anaphylactic shock involves immediate removal of the allergen, followed by subcutaneous or intravenous administration of 0.5 mg epinephrine. Glucocorticoids, antihistamines, rapid fluid resuscitation, and supplemental oxygen are also critical components of initial therapy.
Anaphylactic shock is characterized by an IgE-mediated hypersensitivity reaction involving multi-organ injury, commonly triggered by medication. Most patients develop symptoms during drug administration, and fever is typically not proportional to other clinical manifestations.
Initial management of anaphylactic shock requires immediate removal of the allergen, followed by subcutaneous or intravenous injection of 0.5 mg epinephrine. Corticosteroids, antihistamines, rapid fluid resuscitation, and supplemental oxygen constitute critical components of initial therapy.
In cases of cardiac arrest secondary to anaphylaxis, epinephrine dosage should be rapidly escalated. Clinicians should note that epinephrine may be ineffective in patients chronically receiving beta-blockers.
For patients presenting with hoarseness, tongue swelling, or oropharyngeal edema, early endotracheal intubation is recommended to relieve upper airway obstruction and ensure airway patency.
