Should heparin be administered for hyperfibrinolysis?
Nov 22, 2022
Source: Cainiu Health
Dr. Yang Shuwen
Introduction
In general, heparin should not be administered in cases of hyperfibrinolysis. Hyperfibrinolysis indicates excessive breakdown of fibrinogen and leads to significant consumption of coagulation factors in the patient's body, resulting in a series of bleeding symptoms. Heparin can exacerbate hyperfibrinolysis by further promoting overactivity of the fibrinolytic system, as hyperfibrinolysis is caused by excessive activation of plasminogen.
In general, heparin should not be administered in cases of hyperfibrinolysis. The detailed explanation is as follows:
Hyperfibrinolysis indicates excessive breakdown of fibrinogen and consumes large amounts of coagulation factors in the patient's body, leading to a series of bleeding symptoms. Heparin can exacerbate hyperfibrinolysis, causing overactivation of the fibrinolytic system. Hyperfibrinolysis occurs due to excessive activation of plasminogen, resulting in increased plasmin production, which in turn causes excessive degradation of fibrinogen and subsequent bleeding. In patients with hyperfibrinolysis who already have severe bleeding, hypovolemic shock may occur. Heparin acts by enhancing the activity of antithrombin to achieve anticoagulant effects; however, this further reduces antithrombin activity. Administering heparin under such conditions would worsen the bleeding. Therefore, heparin should not be used in cases of hyperfibrinolysis.
Note: In daily life, it is recommended to consume more nutritious foods, such as eggs and milk.
