Is hyperfibrinolysis associated with bleeding or thrombosis?
May 16, 2023
Source: Cainiu Health
Dr. Pan Yongyuan
Introduction
Excessive fibrinolysis can lead to bleeding. When fibrinolysis is excessively activated due to various causes, it results in the excessive breakdown of fibrinogen and the consumption of various coagulation factors. As a result, patients may develop a series of bleeding symptoms, such as nosebleeds, hematochezia, and hematuria. It is recommended to seek medical attention at a hospital and receive targeted treatment based on individual health conditions.
In general, hyperfibrinolysis can lead to bleeding. The detailed analysis is as follows:
Hyperfibrinolysis refers to the abnormal enhancement of fibrin degradation during the coagulation process and can be classified into two types: primary and secondary. Primary hyperfibrinolysis is mostly caused by surgical or obstetric complications, while secondary hyperfibrinolysis is commonly triggered by factors such as surgery, trauma, severe hepatitis, and infectious diseases. Clinically, it is most frequently observed in the late stages of disseminated intravascular coagulation (DIC). When hyperfibrinolysis occurs due to various causes, excessive breakdown of fibrinogen happens along with depletion of multiple coagulation factors, leading patients to develop a series of hemorrhagic symptoms. Therefore, hyperfibrinolysis results in bleeding manifestations such as epistaxis, hematochezia, and hematuria.
Patients are advised to seek medical attention at a hospital and, based on their specific condition, receive treatment under a doctor's guidance using medications such as aminobenzoic acid tablets or tranexamic acid tablets. In addition to medication, administration of lyophilized human fibrinogen or fresh plasma may also be used. If necessary, patients should go to the hospital for evaluation and management, where doctors will develop an appropriate treatment plan. Patients experiencing any discomfort should promptly seek medical care.
