Five Major Causes of Vasculitis
Feb 25, 2023
Source: Cainiu Health
Dr. Liu Aihua
Introduction
Vasculitis is a common disease, and its five major causes include immune system disorders, infections, genetic factors, antibodies, and lymphocytes. Vasculitis may result from immune system dysfunction, in which the immune system mistakenly identifies body tissues or bacteria as foreign substances, thereby triggering vasculitis. In addition, certain chemicals may cause vasculitis, especially sulfuric acid and chloroform.
Vasculitis is a common disease, and its five major causes include immune system disorders, infections, genetic factors, antibodies, and lymphocytes.
1. Immune System Disorders
Vasculitis may result from immune system dysregulation, in which the immune system mistakenly identifies body tissues or bacteria as foreign substances, leading to the development of vasculitis. Specific manifestations include fever, night sweats, ischemia of affected blood vessels, and organ dysfunction.
2. Infections
Bacterial, viral, and fungal infections can all trigger vasculitis. Examples include hepatitis virus, Coxsackie virus, and influenza virus.
3. Genetic Factors
Certain genetic factors may contribute to vasculitis, particularly hereditary vasculitic diseases such as vasculitic myopathy and vasculitic liver disease.
4. Antibodies
Antineutrophil cytoplasmic antibodies (ANCA) are found in systemic necrotizing vasculitis, and anti-endothelial cell antibodies have been detected in vasculitis.
5. Lymphocytes
T lymphocytes, especially CD4+ T lymphocytes, are directly associated with large vessel vasculitis. This process resembles delayed-type hypersensitivity.
In addition, certain chemicals may induce vasculitis, particularly sulfuric acid, chloroform, and nitrates. Patients are advised to undergo appropriate examinations and actively cooperate with treatment under medical supervision to effectively control disease progression and prevent or minimize damage to various organs and systems in the body.
