Will C-reactive protein be elevated in gout?
Mar 27, 2023
Source: Cainiu Health
Dr. Liu Aihua
Introduction
Gout may cause an increase in C-reactive protein. Gout results from metabolic abnormalities that lead to excessive accumulation of urate salts in the body, triggering acute or chronic inflammatory responses and tissue damage. The underlying mechanism primarily involves crystals of sodium urate, which induce a significant increase in white blood cells within the joint synovial fluid and promote the release of chemotactic factors such as leukotrienes.
Gout may cause an increase in C-reactive protein (CRP).
Gout results from metabolic abnormalities in the body that lead to excessive accumulation of uric acid salts, triggering acute or chronic inflammatory responses and tissue damage. The primary cause is the deposition of monosodium urate crystals, which significantly increases white blood cells within the joint synovial fluid. These crystals also promote the release of chemotactic factors such as leukotrienes, leading to infiltration of inflammatory cells including monocytes and macrophages, ultimately resulting in tissue injury and the development of gout.
Gout can elevate C-reactive protein levels because CRP is a marker of inflammation. The rise in CRP during gout occurs mainly due to damage to the synovial membrane of joints, which triggers an inflammatory response. Additionally, gout can increase CRP by damaging vascular endothelium and kidneys. Therefore, elevated CRP levels may occur not only in affected joints but also in other parts of the body.
Thus, patients experiencing an acute gout attack should seek timely medical treatment.
