The detoxification mechanisms of atropine and pralidoxime iodide
Mar 28, 2023
Source: Cainiu Health
Dr. Yang Shuwen
Introduction
The detoxification mechanism of atropine involves blocking the action of acetylcholine at nerve endings, while that of pralidoxime iodide is to inhibit the effects of organophosphorus pesticides on the nervous system. Therefore, both atropine and pralidoxime iodide are antidotes used to alleviate symptoms of organophosphorus pesticide poisoning. It should be noted that these antidotes must be used under the guidance of a physician.
Atropine works as an antidote by blocking the action of acetylcholine at nerve endings, while pralidoxime iodide counteracts poisoning by inhibiting the effects of organophosphate pesticides on the nervous system. A detailed analysis is as follows:
1. Atropine
Atropine is an anticholinergic drug that blocks the action of acetylcholine at nerve endings, thereby reducing the impact of organophosphate pesticides on the nervous system. Additionally, atropine can dilate the bronchi and reduce secretions, thus improving respiratory symptoms.
2. Pralidoxime Iodide
Pralidoxime iodide is a phosphorylase enzyme inhibitor that suppresses the effects of organophosphate pesticides on the nervous system. It binds with organophosphate pesticides to form inactive complexes, thereby reducing their neurotoxic effects.
Both atropine and pralidoxime iodide are antidotes used to alleviate symptoms of organophosphate pesticide poisoning. It is important to note that when using these antidotes, appropriate dosage and administration routes should be selected based on the severity of poisoning and clinical symptoms, and they must be used under medical supervision.
