Normal value of blood β2-MG
Mar 29, 2023
Source: Cainiu Health
Dr. Yang Shuwen
Introduction
β2-microglobulin (β2-MG) is a muscle protein whose normal levels vary depending on factors such as gender, age, and physical condition. The normal range for serum β2-MG in adult males is 0.6–6.0 μg/mL, while for adult females it is 0.6–5.0 μg/mL. However, testing methods and reference standards may vary slightly among different laboratories.
Under normal circumstances, the reference range for serum β2-microglobulin (β2-MG) is 1–2 mg/L. This value can be used to assess kidney function and to detect certain diseases. A detailed analysis is as follows:
β2-MG is a globulin secreted by nucleated cells and is produced by various cells including lymphocytes and platelets. It can be found in plasma, urine, cerebrospinal fluid, saliva, and other body fluids. Normally, the level of serum β2-MG in the human body is very low. It is almost completely reabsorbed in the proximal tubules of the kidneys. In healthy adults, the serum concentration of β2-MG is approximately 1–2 mg/L, though levels may vary slightly among individuals. Serum β2-MG serves as an indicator of renal function. When kidney filtration capacity is impaired, β2-MG accumulates in the blood, leading to elevated blood concentrations. Additionally, increased production of β2-MG can occur in various conditions such as IgG nephropathy, malignant tumors, hepatitis, rheumatoid arthritis, and other inflammatory diseases.
If any of the above symptoms are present or if serum β2-MG levels are abnormal, it is essential to seek medical evaluation promptly to avoid delays in treatment.
