How to interpret immunohistochemistry results for breast cancer

Apr 24, 2023 Source: Cainiu Health

Dr. Lv Aiming

Introduction

Breast cancer immunohistochemical results can be evaluated based on ER, PR, Ki67, and Her-2. Estrogen receptor (ER) is a type of protein molecule. After patients receive endocrine therapy, this marker usually shows significant changes. If the result is positive, it indicates that this treatment approach is effective. Patients are advised to proceed with further treatment according to their individual test results.

Breast cancer immunohistochemical results can be interpreted through ER, PR, Ki67, and Her-2. The specific analysis is as follows:

1. ER

Estrogen receptor, a type of protein molecule. After patients receive endocrine therapy, this marker usually shows significant changes. A positive result indicates that this treatment approach is effective.

2. PR

Progesterone receptor, a protein located within target cells that mediates the effects of progesterone. Similar to ER, a positive result suggests a better prognosis.

3. Ki67

A marker antigen associated with proliferating cells and essential for cell division. A positive result typically indicates a poor prognosis.

4. Her-2

Human epidermal growth factor receptor 2, also one of the genes associated with breast cancer. A positive result often indicates a higher likelihood of metastasis and a poorer prognosis.

Patients are advised to proceed with further treatment based on their individual test results.

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