Is there a disulfiram-like reaction with cefaclor?
Apr 26, 2023
Source: Cainiu Health
Dr. Yang Shuwen
Introduction
Cefaclor generally does not cause disulfiram-like reactions. Cefaclor is a β-lactam antibiotic belonging to the second-generation cephalosporins. Its molecular structure does not contain a methylthiotetrazole group, so it does not interfere with ethanol metabolism in the body and therefore does not lead to disulfiram-like reactions. However, alcohol consumption should be avoided during treatment to prevent increased burden on the liver and kidneys.
Cefaclor generally does not cause disulfiram-like reactions, but alcohol consumption should be avoided during treatment to prevent potential liver and kidney damage. The detailed explanation is as follows:
Cefaclor is a β-lactam antibiotic belonging to the second-generation cephalosporins. Its molecular structure does not contain a methylthiotetrazole group, so it does not interfere with ethanol metabolism in the body, and therefore does not lead to disulfiram-like reactions. Disulfiram-like reactions typically occur when using certain cephalosporins—such as cefoperazone sodium and sulbactam sodium—that contain chemical structures inhibiting the further oxidation of acetaldehyde. Alcohol consumption during treatment with these drugs can inhibit alcohol metabolism, leading to acetaldehyde accumulation and toxicity. Although cefaclor does not cause such reactions, drinking alcohol should still be avoided during therapy to prevent additional strain on the liver and kidneys.
Patients are advised to use medications appropriately under the guidance of a physician and avoid self-medication that may lead to adverse effects.
