Why does blood sugar increase after taking dapagliflozin?
Apr 29, 2023
Source: Cainiu Health
Dr. Pan Yongyuan
Introduction
Dapagliflozin is generally used to treat type 2 diabetes based on diet and exercise. If blood glucose levels rise after taking dapagliflozin, it is usually related to insufficient dosage, excessive dosage, or the development of drug resistance. Patients are advised to maintain a regular lifestyle, avoid staying up late, ensure adequate rest, avoid excessive fatigue, manage their diet properly, and monitor blood glucose levels regularly.
Dapagliflozin is generally used to treat type 2 diabetes. If blood glucose levels paradoxically increase after taking dapagliflozin, this situation is usually related to insufficient dosage, excessive dosage, or the development of drug resistance. The specific details are as follows:
1. Insufficient dosage
If patients do not take the medication on time as prescribed or use an inadequate dose, the drug concentration in the bloodstream may be too low to achieve effective glucose-lowering effects, which could lead to elevated blood glucose levels.
2. Excessive dosage
Dapagliflozin lowers blood glucose by reducing renal reabsorption of glucose. However, if the dose is too high, it may cause hypoglycemia, triggering the body's compensatory mechanisms and resulting in rebound hyperglycemia, thereby increasing blood glucose levels.
3. Development of drug resistance
If patients use dapagliflozin for a prolonged period, their bodies may develop resistance to the drug, leading to paradoxical increases in blood glucose after taking it. In such cases, patients should consult their doctors to switch medications; alternatives may include metformin extended-release tablets or gliclazide tablets.
Patients are advised to maintain a regular lifestyle, avoid staying up late, ensure adequate rest, prevent excessive fatigue, manage their diet properly, monitor blood glucose regularly, attend follow-up appointments as scheduled, and seek medical attention promptly if any discomfort occurs, to avoid adverse effects on health.
