Is "big three positive" indicative of acute hepatitis or chronic hepatitis?

May 10, 2023 Source: Cainiu Health

Dr. Jiang Weimin

Introduction

"Big three positives" may indicate either acute hepatitis or chronic hepatitis. If symptoms such as fatigue, nausea, vomiting, and abdominal pain appear within weeks or months, accompanied by abnormal liver function tests, and the illness lasts less than six months, it is classified as acute hepatitis. Acute hepatitis has no specific effective treatment and may progress to chronic hepatitis. When the disease duration exceeds six months, it is considered chronic hepatitis.

　　"Big three positives" may indicate either acute hepatitis or chronic hepatitis, depending on clinical symptoms, duration, and other factors. The specific analysis is as follows:

　　1. Acute Hepatitis

　　"Big three positives" refers to the serological test results showing positivity in three markers after infection with the hepatitis B virus. If symptoms such as fatigue, nausea, vomiting, and abdominal pain develop within weeks or months, accompanied by abnormal liver function tests, and the illness lasts less than six months, it is typically diagnosed as acute hepatitis.

　　2. Chronic Hepatitis

　　If patients with acute hepatitis do not receive timely and effective treatment, the condition may progress to chronic hepatitis. When the disease duration exceeds six months, it is classified as chronic hepatitis. Symptoms are generally mild or absent, although some patients may experience loss of appetite, nausea, diarrhea, or other discomforts.

　　Patients definitively diagnosed with "big three positives" should actively seek treatment under medical supervision to minimize adverse effects of the disease.

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Many small red spots appeared on the body of a person with hepatitis B "big three positives"

The appearance of numerous small red spots on the body in patients with hepatitis B "big three positive" may be caused by factors such as low immunity, skin allergies, or coagulation disorders, and timely medical evaluation and treatment are recommended. If the liver in patients with hepatitis B "big three positive" fails to properly metabolize the virus, it may lead to rashes. Patients can alleviate symptoms through appropriate exercise, and when necessary, may take lamivudine capsules under a doctor's guidance.

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What causes flank pain and back pain in hepatitis B "big three positives"? What should be done?

Pain and distension in both sides of the rib cage, along with back pain, in individuals with hepatitis B "big three positive" may be caused by physiological factors or pathological factors such as thoracic spine trauma or liver damage, requiring targeted treatment. If adequate rest is not observed during illness and excessive physical labor is performed, the condition may worsen, leading to such symptoms.

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Can a mother with "big three positive" (positive for HBsAg, HBeAg, and anti-HBc) pass it on to her child?

Mothers with "big three positives" generally do not pass the condition on genetically to their children, but they may transmit the infection. "Big three positives" refers to positive results for hepatitis B surface antigen, hepatitis B e-antigen, and hepatitis B core antibody, which typically indicate a person is infected with chronic viral hepatitis B. Since chronic viral hepatitis B is an infectious disease rather than a genetic disorder, it is not inherited by offspring.