How is the H. pylori C13DOB value graded?
May 15, 2023
Source: Cainiu Health
Dr. Zhou Chao
Introduction
The C13 breath test determines whether a patient is infected with Helicobacter pylori by measuring the ratio of carbon-13 (C13) to carbon-12 (C12) isotopes in the exhaled breath. The results of the C13 breath test are typically expressed as the C13 delta over baseline (DOB) value, with higher DOB values indicating a more severe Helicobacter pylori infection. Therefore, specific classification criteria should be comprehensively evaluated based on actual conditions and clinical experience.
The C13 urea breath test determines whether a patient is infected with Helicobacter pylori by measuring the ratio of carbon-13 (C13) to carbon-12 (C12) isotopes in their exhaled breath. The results of the C13 urea breath test are typically expressed as the C13 delta over baseline (DOB) value, with higher DOB values indicating more severe H. pylori infection. There are slight variations in how DOB values are used to classify the severity of H. pylori infection, but generally, the following grading system is applied: detailed analysis is as follows:
1. DOB < -4‰
A DOB value less than -4‰ is considered negative, indicating no H. pylori infection.
2. -4‰ ≤ DOB < 0‰
A DOB value between -4‰ and 0‰ indicates a mild H. pylori infection.
3. 0‰ ≤ DOB < 2.5‰
A DOB value between 0‰ and 2.5‰ indicates moderate infection, which requires active treatment.
4. DOB ≥ 2.5‰
A DOB value of 2.5‰ or higher indicates severe infection, which also requires active treatment.
Additionally, different studies may use slightly different cutoff values for DOB, so the specific criteria should be interpreted based on clinical context and professional judgment.
