What disease is characterized by positive IgA lambda-type M protein?
May 15, 2023
Source: Cainiu Health
Dr. Zhou Chao
Introduction
A positive IgAλ-type M protein is a test result indicating immunoglobulin abnormality, usually suggesting an abnormal immune response in the body. A positive IgAλ-type M protein may be associated with diseases such as rheumatoid arthritis, monoclonal gammopathy, or Salmonella infection. Specifically, rheumatoid arthritis is a chronic autoimmune disease.
IgAλ-type M protein positivity is a test result indicating abnormal immunoglobulin levels, usually suggesting an abnormal immune response in the body. IgAλ-type M protein positivity may be associated with conditions such as rheumatoid arthritis, monoclonal gammopathy, or Salmonella infection. Specific analyses are as follows:
1. Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disease that may cause symptoms including joint pain, swelling, and restricted movement. In some RA patients, production of IgAλ-type M protein may occur.
2. Monoclonal Gammopathy
Monoclonal gammopathy is a benign immune disorder caused by a single clone of plasma cells producing M proteins, typically IgM. Patients with monoclonal gammopathy are often asymptomatic, but in rare cases, it may progress to malignant plasma cell disorders.
3. Salmonella Infection
Salmonella infection is a bacterial illness caused by Salmonella bacteria, which may lead to symptoms such as fever, diarrhea, and abdominal pain. The infection can result in abnormal laboratory test results.
Besides the above-mentioned conditions, IgAλ-type M protein positivity could also be caused by chronic lymphocytic leukemia or multiple myeloma. For patients with abnormal test results, physicians need to conduct a comprehensive evaluation—including clinical presentation, medical history, and other test findings—to determine whether further treatment is necessary.
