Which vitamin malabsorption can be caused by colchicine?

May 15, 2023 Source: Cainiu Health

Dr. Liu Aihua

Introduction

Colchicine refers to colchicine tablets. Colchicine tablets may cause reversible vitamin B12 malabsorption. Detailed analysis is as follows: Colchicine tablets are used to treat acute attacks of gouty arthritis and also to prevent acute episodes of recurrent gouty arthritis. If a patient needs to take colchicine tablets long-term due to medical conditions.

Generally, colchicine refers to colchicine tablets. Colchicine tablets may cause reversible vitamin B12 malabsorption. The specific analysis is as follows:

Colchicine tablets are medications used to treat acute attacks of gouty arthritis and to prevent recurrent acute episodes of gouty arthritis. If patients need to take colchicine tablets long-term due to medical conditions, the medication may inhibit gastric acid secretion, leading to reduced gastric acid concentration. Gastric acid is an important digestive fluid that not only aids in food digestion but also provides necessary conditions for vitamin B12 absorption. If gastric acid secretion is impaired, decreased gastric acid levels may consequently affect vitamin B12 absorption, potentially leading to vitamin B12 deficiency and anemia. It should be noted that vitamin B12 malabsorption caused by colchicine is usually reversible; after discontinuation of colchicine tablets, gastric acid secretion and vitamin B12 absorption capacity gradually return to normal.

Patients taking colchicine tablets should strictly follow their doctor's instructions, avoiding arbitrary dosage adjustments or stopping the medication without consultation, to prevent compromising treatment efficacy. If any adverse symptoms occur, prompt medical attention is advised.

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