What are the short-acting glucocorticoids?

May 16, 2023 Source: Cainiu Health

Dr. Pan Yongyuan

Introduction

Short-acting corticosteroids include hydrocortisone acetate tablets, hydrocortisone butyrate cream, and cortisone acetate eye drops, which have anti-inflammatory and antiallergic effects. These medications must be used strictly as directed by a physician. Individuals allergic to steroids should avoid using them. If discomfort occurs after taking the medication, seek medical attention promptly to prevent adverse reactions.

Short-acting glucocorticoids include hydrocortisone acetate tablets, hydrocortisone butyrate cream, and cortisone acetate eye drops. The details are as follows:

1. Hydrocortisone Acetate Tablets

Hydrocortisone acetate tablets belong to the class of glucocorticoid drugs and have anti-inflammatory, antiallergic, and immunosuppressive effects. They can be used to treat conditions such as rheumatoid arthritis, gout, or bronchial asthma. Possible side effects after taking the medication include nausea, vomiting, and menstrual disorders. Therefore, it is essential to follow a doctor's instructions when taking this medication, as improper use may lead to more severe side effects. Do not discontinue the medication abruptly without medical advice. This drug must not be used by individuals who are allergic to corticosteroids.

2. Hydrocortisone Butyrate Cream

Hydrocortisone butyrate cream is a topical glucocorticoid with anti-inflammatory, antiallergic, and antipruritic effects. It can be used to treat allergic dermatitis, seborrheic dermatitis, allergic eczema, and similar skin conditions. If redness, swelling, or a burning sensation occurs during use, discontinue immediately. Prolonged use of this medication is not recommended, as it may lead to adverse reactions.

3. Cortisone Acetate Eye Drops

Cortisone acetate eye drops have anti-inflammatory and antiallergic properties and are used in the treatment of allergic conjunctivitis. This medication should not be used for extended periods. It should not be used alone when there is an ocular infection present. Always use as directed by a physician.

If discomfort occurs after using any of these medications, seek prompt medical attention to prevent potential adverse reactions.

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What Are the Effects of Glucocorticoids on Fertility?

Long-term use of glucocorticoids—such as cortisol and prednisone—can suppress the hypothalamic-pituitary-adrenal (or gonadal) axis, leading to erectile dysfunction, decreased libido, and reduced sperm production in men; it may also impair sexual function and cause infertility. In women, such use may result in adrenal cortical insufficiency—or even atrophy—menstrual cessation (amenorrhea), and infertility.

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What precautions should be taken when using glucocorticoids and cytotoxic drugs?

Precautions when using glucocorticoids: 1. Monitor for adverse reactions; 2. Be vigilant for withdrawal reactions and rebound phenomena. Cytotoxic drugs may cause toxicity—including to the reproductive, urinary, hepatic, and renal systems—as well as teratogenic effects, via routes such as skin contact or inhalation. Therefore, standardized procedures must be followed during preparation of cytotoxic drugs, and appropriate occupational protective measures must be implemented.

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What are the contraindications of glucocorticoids?

Contraindications for glucocorticoids typically include cautious use in patients with hypersensitivity, avoidance of high-dose administration, and cautious use in patients with tuberculosis or viral infections. Patients with heightened sensitivity should use glucocorticoids with caution to prevent allergic reactions. High-dose administration should be avoided to prevent complications such as diabetes mellitus or secondary infections. Glucocorticoids should be used cautiously in patients with tuberculosis or viral infections, as they may elevate blood pressure and increase the risk of cerebrovascular accidents.

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What are the clinical uses of glucocorticoids?