What does HLA-B27 gene testing mean?
May 16, 2023
Source: Cainiu Health
Dr. Liu Aihua
Introduction
HLA-B27 gene testing is a genetic test used to determine whether an individual carries the HLA-B27 gene, which is associated with autoimmune diseases such as rheumatoid arthritis and ankylosing spondylitis. A positive test result does not necessarily mean that a person has these diseases, but it may indicate an increased risk. It is important to have thorough communication and discussion with a doctor before undergoing the test.
Generally, HLA-B27 gene testing is a common genetic test used to determine whether an individual carries this gene. The specific analysis is as follows:
HLA-B27 gene testing detects the presence of the HLA-B27 gene in human cells to determine whether this antigen exists in the body. HLA-B27 is a member of the human leukocyte antigen (HLA) family and is primarily found in the immune system. It helps the body recognize and combat foreign invaders such as bacteria and viruses by interacting or binding with other proteins. Under normal circumstances, the presence of this antigen may trigger the immune system to attack and damage the body's own tissues, leading to various autoimmune diseases, such as ankylosing spondylitis and psoriatic arthritis. Therefore, gene testing serves as a tool to assist doctors in diagnosing diseases, but it must be interpreted in conjunction with the patient’s symptoms, physical signs, and other test results.
It should be noted that the HLA-B27 gene is also associated with many other diseases and conditions. Hence, prior to testing, it is important to have thorough communication and discussion with a physician to ensure the purpose and necessity of the test. Testing should be conducted at professional medical institutions and laboratories.
