What is lei gland disease, and is it serious?

May 16, 2023 Source: Cainiu Health

Dr. Yang Shuwen

Introduction

"CIN3 with glandular involvement" generally refers to CIN3 extending into the cervical glands. This represents a special manifestation of CIN3, indicating that the precancerous changes have spread into the glandular epithelium of the cervix and are in an advanced stage of transformation, requiring more aggressive treatment. The severity of CIN3 with glandular involvement depends on the extent and degree of the lesion. Regular cervical cancer screening is essential for early detection and timely management of CIN3 with glandular involvement.

In general, "involvement of glands" usually refers to CIN3 involving the glandular epithelium. CIN3 with glandular involvement is a special manifestation of CIN3, indicating that the precancerous changes have spread into the cervical glandular structures and represent an advanced stage of transformation, which is generally considered more serious and requires more aggressive treatment. A detailed analysis is as follows:

CIN3 (cervical intraepithelial neoplasia grade 3) represents the most severe degree of cervical intraepithelial neoplasia, indicating a very high risk of malignant transformation. Cervical intraepithelial neoplasia is a precancerous condition of cervical cancer and is classified into three stages: CIN1, CIN2, and CIN3. CIN3, also known as high-grade lesion, carries a particularly high risk of progressing to invasive cancer. The severity of CIN3 with glandular involvement depends on the extent and spread of the lesion. If the affected area is small, it may be treated effectively with simple interventions such as surgical excision or cryotherapy. However, if the lesion is extensive or involves deeper layers of cervical tissue, more complex and aggressive treatments—such as radiation therapy, surgical removal (e.g., cone biopsy or hysterectomy), or chemotherapy—may be necessary.

It is recommended to undergo regular cervical cancer screening to detect and treat CIN3 with glandular involvement at an early stage, thereby preventing the development of cervical cancer. Additionally, maintaining healthy lifestyle habits, good personal hygiene, and overall health can help reduce the risk of developing this condition.

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