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Clinical significance of markedly elevated FDP and DD

May 31, 2023 Source: Cainiu Health
Dr. Lin Yunfei
Introduction
DD usually refers to D-dimer. FDP and D-dimer are laboratory indicators in routine coagulation tests. Under normal circumstances, the coagulation and fibrinolysis systems in the body maintain a dynamic balance, allowing blood to remain fluid within blood vessels. When both of these markers are elevated, it may indicate conditions such as disseminated intravascular coagulation, thromboangiitis obliterans, or pulmonary thromboembolism.

DD usually refers to D-dimer. FDP and D-dimer are laboratory indicators in routine coagulation tests. Under normal circumstances, the coagulation and fibrinolysis systems in the body maintain a dynamic balance, allowing blood to remain fluid within blood vessels. If both values increase, it may indicate possible conditions such as disseminated intravascular coagulation (DIC), thromboangiitis obliterans, or pulmonary thromboembolism. Specific analyses are as follows:

1. Disseminated Intravascular Coagulation (DIC)

This condition often results from persistent myocardial ischemia caused by DIC. Clinical manifestations include compressive pain behind the sternum. Due to DIC-induced vascular narrowing, FDP and D-dimer levels also rise during testing. Patients should follow medical advice to use medications such as enteric-coated aspirin tablets or clopidogrel hydrogen sulfate tablets.

2. Thromboangiitis Obliterans

When this disease occurs, elevated FDP and D-dimer levels can also be observed, requiring symptomatic treatment. Patients with thromboangiitis obliterans may take medications such as enteric-coated aspirin tablets or clopidogrel tablets under medical guidance, or undergo surgical treatments such as endovascular minimally invasive surgery.

3. Pulmonary Thromboembolism

This condition commonly occurs in individuals who have been bedridden for long periods or have deep vein thrombosis in the lower limbs. Main symptoms include dyspnea, chest pain, and hemoptysis. Because of activated thrombus formation and fibrinolytic activity within blood vessels, laboratory tests show increased FDP and D-dimer levels. For patients diagnosed with this condition, anticoagulant medications such as rivaroxaban tablets or apixaban tablets can be taken under a doctor's supervision.

In addition, elevated levels may also result from idiopathic thrombocytopenic purpura, chronic obstructive pulmonary disease (COPD), acute myocardial infarction, and other conditions. It is recommended that patients pay close attention to abnormal elevations in FDP and D-dimer, seek timely medical evaluation at a qualified hospital, and avoid delays in treatment.


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