Can taking antidepressants cause elevated transaminase levels?
Jun 02, 2023
Source: Cainiu Health
Dr. Zhu Gang
Introduction
Taking antidepressants usually leads to elevated transaminase levels. If patients take antidepressant medications long-term or develop symptoms of liver disease, such as jaundice, loss of appetite, or abdominal pain, they should seek medical attention promptly for evaluation and treatment. Liver function tests are recommended; if elevated transaminases are detected, the dosage of the medication should be reduced or switched to an alternative drug.
Taking antidepressants often leads to elevated transaminase levels. The detailed analysis is as follows:
Antidepressants are a common treatment for depression, but their components may affect the liver, leading to increased transaminase levels. Transaminases are a type of enzyme, commonly including aspartate aminotransferase (AST) and alanine aminotransferase (ALT). These enzymes primarily exist in the liver and other organs. When liver cells are damaged, these enzymes are released into the bloodstream, causing elevated transaminase levels. If patients take antidepressants long-term or in excessive doses, it may overload the liver, resulting in increased transaminase levels. For patients who already have liver disease, antidepressants may exert a greater impact on the liver, further elevating transaminase levels.
If patients take antidepressants for prolonged periods or develop symptoms of liver disease—such as jaundice, loss of appetite, or abdominal pain—they should seek medical attention promptly for evaluation and treatment. Liver function tests are recommended; if elevated transaminases are detected, the dosage should be reduced or the medication changed. During treatment, patients should pay attention to diet and lifestyle habits, avoiding alcohol abuse and improper use of medications to reduce the burden on the liver.
