Why do I feel worse after taking duloxetine, and what should I do?
Jun 02, 2023
Source: Cainiu Health
Dr. Zhu Gang
Introduction
Feeling worse after taking duloxetine may be due to the drug's mechanism of action, side effects, worsening of the underlying condition, or other reasons such as inappropriate medication. This can be improved through general treatments or adjusting medications. If symptoms do not improve or worsen during treatment, it is important to seek medical attention promptly.
Feeling worse after taking duloxetine may be due to the drug's mechanism of action, side effects, worsening of the underlying condition, or other reasons. Symptoms can be improved through general treatments, medication adjustments, and other methods. A detailed analysis is as follows:
1. Mechanism of Action
Duloxetine alleviates depressive symptoms by inhibiting the reuptake of norepinephrine and serotonin. However, at the beginning of treatment, this may temporarily increase neurotransmitter levels, leading to a transient worsening of symptoms.
2. Side Effects
Duloxetine may cause side effects such as dizziness, nausea, insomnia, anxiety, and fatigue, which can make patients feel unwell after starting the medication. If these symptoms occur, it is important to discontinue the drug and consult a doctor for possible adjustment or replacement of the medication.
3. Worsening of the Condition
Some patients may have varying presentations of depression, or may already have had severe symptoms before starting duloxetine, which could contribute to the perception of worsening symptoms. In such cases, symptom management should not rely solely on medication but should also include psychotherapy, physical therapy, and other comprehensive approaches.
In addition to the above reasons, inappropriate medication selection may also contribute to symptom exacerbation. If symptoms fail to improve or worsen during treatment, prompt medical evaluation at a hospital is necessary.
