What does it mean when cystatin C is low?
Jun 05, 2023
Source: Cainiu Health
Dr. Yang Shuwen
Introduction
Low cystatin C levels usually indicate that the glomerular filtration function is essentially intact. The detailed explanation is as follows: Cystatin C is a marker reflecting glomerular filtration rate (GFR). It is primarily excreted through the kidneys, filtered by the glomeruli, and almost completely reabsorbed by the renal tubules. Moreover, its level is not affected by factors such as gender, age, body weight, or diet.
Cystatin C levels below the normal range usually indicate that glomerular filtration function is essentially intact. The detailed analysis is as follows:
Cystatin C is a marker reflecting glomerular filtration rate (GFR). It is primarily excreted through the kidneys, filtered by the glomeruli, and almost completely reabsorbed by the renal tubules. Its level is not significantly affected by factors such as gender, age, body weight, or diet. Therefore, in clinical practice, it is a commonly used indicator for evaluating kidney function, especially important for patients with diabetic nephropathy, hypertensive nephropathy, and chronic kidney disease. A decreased cystatin C level typically suggests that glomerular filtration function is basically normal, whereas an elevated level often indicates reduced glomerular filtration rate and may signal an increased risk of kidney disease.
If cystatin C levels are found to be elevated, patients should promptly seek medical attention at a hospital and undergo standardized evaluation and treatment under a physician's guidance to determine the underlying cause.
