What is the pathogenesis of chronic glomerulonephritis?
Jun 05, 2023
Source: Cainiu Health
Dr. Zhao Xinju
Introduction
The pathogenesis of chronic glomerulonephritis is usually associated with genetic factors, environmental factors, and inflammatory infections. Chronic glomerulonephritis is a gradually progressive inflammatory disease of the glomeruli that has a certain genetic predisposition. Some patients may have gene mutations or genetic defects, leading to abnormal immune function or impaired glomerular filtration, thereby causing chronic glomerulonephritis.
The pathogenesis of chronic glomerulonephritis is usually associated with genetic factors, environmental factors, inflammatory infections, and others. A detailed analysis is as follows:
1. Genetic Factors
Chronic glomerulonephritis is a gradually progressive inflammatory disease of the glomeruli that has certain genetic predispositions. Some patients may have gene mutations or hereditary defects, leading to abnormal immune function or impaired glomerular filtration, thereby causing chronic glomerulonephritis.
2. Environmental Factors
If patients are long-term exposed to harmful substances, chemicals, drugs, or other hazardous environments due to work or other reasons, their immune function may be compromised, resulting in impaired glomerular filtration and subsequently triggering chronic glomerulonephritis.
3. Inflammatory Infections
If patients with low immunity become infected with bacteria or viruses and do not receive timely treatment, inflammatory lesions may develop in the body, which can easily affect the glomeruli and lead to chronic inflammatory changes.
In addition to the common mechanisms mentioned above, chronic glomerulonephritis may also be related to immune system disorders, metabolic abnormalities, and other factors. Patients diagnosed with chronic glomerulonephritis should promptly cooperate with their doctors for targeted treatment to prevent disease progression.
