How long should a disulfiram-like reaction be observed?
Aug 25, 2023
Source: Cainiu Health
Dr. Yang Shuwen
Introduction
In general, disulfiram-like reactions should be observed for 48 hours. A disulfiram-like reaction refers to a series of adverse effects that occur when a patient consumes alcohol during treatment with disulfiram-like drugs, primarily manifesting as allergic inflammatory responses in the skin and mucous membranes. The onset of a disulfiram-like reaction typically occurs within minutes to several hours after alcohol ingestion.
In general, patients should be observed for 48 hours for disulfiram-like reactions. The detailed explanation is as follows:
A disulfiram-like reaction refers to a series of adverse effects that occur when a patient consumes alcohol while taking disulfiram-containing medications, primarily manifesting as allergic inflammatory responses affecting the skin and mucous membranes. Symptoms typically begin within minutes to several hours after alcohol ingestion. Common symptoms include facial flushing, palpitations, nausea, vomiting, headache, chest tightness, elevated blood pressure, and increased heart rate. In severe cases, symptoms may progress to difficulty breathing, coma, or cardiac complications. Observation for disulfiram-like reactions should generally continue for at least 48 hours to ensure that the patient's condition remains stable and manageable. If severe symptoms such as difficulty breathing or signs of myocardial injury occur, immediate medical attention is required.
To avoid potential disulfiram-like reactions, patients are advised to abstain from alcohol for several weeks after discontinuing the medication to prevent adverse effects on health.
