What are the causes of fetal arrest?

Sep 12, 2023 Source: Cainiu Health
Dr. Zhao Xiaodong
Introduction
In general, embryonic arrest may be associated with maternal infections, abnormal embryonic development, thyroid dysfunction, inadequate luteal function, and embryonic chromosomal abnormalities. In addition to the above factors, it may also be related to lifestyle habits, environmental factors, and maternal immune abnormalities. It is recommended that couples planning pregnancy undergo comprehensive preconception examinations, including testing for chromosomal abnormalities.

Generally speaking, fetal arrest may be associated with maternal infections, poor embryonic development, abnormal thyroid function, inadequate luteal function, and embryonic chromosomal abnormalities. The details are as follows:

1. Maternal Infection

When a pregnant woman is infected with certain viruses—such as rubella, toxoplasmosis, or cytomegalovirus—the fetus may develop malformations or even die. It is recommended that women undergo a pre-pregnancy "TORCH panel" (five-item prenatal screening) at the hospital, especially testing for viral antibodies, to confirm whether any harmful viruses are present in the body and prevent adverse effects on fetal development.

2. Poor Embryonic Development

Poor embryonic development includes delayed growth, developmental arrest, or excessive embryonic fragmentation, which may lead to fetal arrest. Women are advised to have a comprehensive physical examination before planning pregnancy. Additionally, folic acid supplementation should begin at least three months prior to conception, and proper nutrition should be maintained after becoming pregnant.

3. Abnormal Thyroid Function

Thyroid dysfunction in pregnant women can cause endocrine disorders that may result in fetal arrest. Individuals with hyperthyroidism or hypothyroidism should be particularly cautious about risks of embryonic arrest or fetal malformations. Since thyroid abnormalities often lack obvious symptoms, it is recommended to undergo thyroid screening before pregnancy and, if necessary, use medication appropriately under medical guidance to manage the condition.

4. Inadequate Luteal Function

If a woman’s ovarian function is impaired, her body may fail to produce sufficient progesterone needed for normal embryonic development, leading to fetal arrest. Women with menstrual irregularities or known luteal phase defects should first regulate their health to restore normal endocrine function before attempting pregnancy. For those who experience fetal arrest due to insufficient luteal function, appropriate progesterone supplementation during pregnancy is recommended to maintain stable hormone levels.

5. Embryonic Chromosomal Abnormalities

Chromosomal abnormalities may occur if either the sperm or the egg carries genetic defects, disrupting normal embryonic development and potentially causing fetal arrest. It is advisable for both partners to undergo chromosomal testing before conception to screen for potential genetic issues.

In addition to the above factors, fetal arrest may also be related to lifestyle habits, environmental factors, and maternal immune system abnormalities. Couples planning a pregnancy are strongly encouraged to undergo comprehensive preconception checkups, including chromosomal analysis, assessment of family genetic history, and evaluation of sperm quality. Only after confirming these factors are normal should pregnancy be pursued.


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