Can calprotectin levels be elevated in patients with irritable bowel syndrome?
Nov 13, 2023
Source: Cainiu Health
Dr. Shen Yonghua
Introduction
Calprotectin refers to calcium-binding protein. In general, calprotectin levels may be elevated in patients with irritable bowel syndrome (IBS); however, in mild cases of IBS, the levels may remain normal. Patients are advised to follow medical instructions for symptomatic treatment. It should be noted that IBS may increase the likelihood of elevated calprotectin, but this is not absolute. If a patient experiences any discomfort or symptoms, prompt medical evaluation at a hospital is recommended.
Calprotectin refers to calcium-binding protein. In general, calprotectin levels may be elevated in patients with irritable bowel syndrome (IBS); however, in mild cases of IBS, the levels may remain normal. Patients are advised to follow medical instructions for symptomatic treatment. Detailed analysis is as follows:
1. Elevated
Irritable bowel syndrome may lead to metabolic disturbances, resulting in abnormally increased calprotectin levels. This may also be accompanied by symptoms such as altered bowel habits and abdominal pain. Calprotectin is a calcium-binding protein derived from neutrophils and macrophages, and in clinical practice, it is commonly used as a biomarker of inflammation. The normal range for calprotectin is 0–50 μg/g. Elevated levels often indicate intestinal inflammation; conditions such as ulcerative colitis, Crohn's disease, and irritable bowel syndrome may all present with increased calprotectin levels.
2. Not elevated
An IBS diagnosis does not always result in elevated calprotectin levels. In patients with mild irritable bowel syndrome who receive timely treatment, calprotectin levels typically remain within the normal range.
If patients experience any discomfort or symptoms, they should promptly seek medical attention at a hospital to avoid delays in diagnosis and treatment.
