What is the effect of denosumab on teeth?

Denosumab usually refers to denosumab injection. Generally, the possible effects of denosumab injection on teeth may include limited mouth opening, dental infections, loose teeth, tooth pain, and periodontal disease. If any discomfort occurs, it is recommended to seek medical attention promptly and receive treatment under a doctor's guidance. Specific analyses are as follows:

1. Limited mouth opening: After treatment with denosumab injection, if symptoms such as periodontal disease or tooth pain fail to improve, patients may experience difficulty in fully opening the mouth, which in severe cases could affect eating.

2. Dental infection: Denosumab injection may reduce the body's resistance to oral bacteria, increasing the risk of dental infections. This is typically associated with suppression of the immune system.

3. Loose teeth: Untreated or inadequately treated dental infections may lead to loosening of teeth and even impair normal chewing function.

4. Tooth pain: Denosumab injection may lead to osteonecrosis of the jaw, particularly in individuals with a history of tooth extraction, poor oral hygiene, or use of dental devices. Symptoms commonly include jaw pain, toothache, gum ulcers, or gingival erosion.

5. Periodontal disease: Periodontal disease refers to inflammation and destruction of periodontal tissues. Denosumab injection may interfere with the immune system’s response to oral bacteria, thereby increasing the risk of developing periodontal disease.

Patients should pay attention to oral health in daily life, remember to brush teeth morning and night, and undergo regular dental check-ups. In terms of diet, hard foods such as nuts and beef jerky should be avoided, as they can easily damage teeth.