What are the effects of bisoprolol on creatinine?
Nov 29, 2023
Source: Cainiu Health
Dr. Wang Xin
Introduction
Bisoprolol is commonly available in tablet and capsule formulations. The effects of bisoprolol on creatinine include uremia, reduced myocardial contractility, altered drug metabolism, impaired muscle metabolism, and renal insufficiency. It is recommended to seek timely medical evaluation at a hospital to determine the underlying cause before initiating medication. Long-term and high-dose use of bisoprolol may lead to tubular injury and decreased glomerular filtration function.
Bisoprolol is commonly available in tablet and capsule formulations. The effects of bisoprolol on creatinine include uremia, reduced myocardial contractility, altered drug metabolism, impaired muscle metabolism, and renal insufficiency. It is recommended to seek timely medical evaluation at a hospital to determine the underlying cause before initiating medication. Detailed explanations are as follows:
1. Uremia
Long-term and high-dose use of bisoprolol may lead to tubular injury, reduce glomerular filtration function, impair normal excretion of creatinine from the body, and thereby induce uremia.
2. Reduced Myocardial Contractility
Bisoprolol may reduce myocardial contractility, leading to decreased cardiac output, which in turn reduces both creatinine production and excretion.
3. Altered Drug Metabolism
Bisoprolol may interfere with the metabolism of other medications, thus affecting creatinine levels. For example, it may alter the metabolism of certain antihypertensive drugs, resulting in elevated creatinine levels.
4. Impaired Muscle Metabolism
Bisoprolol may affect muscle metabolism, reducing muscle catabolism and thereby influencing creatinine production and excretion.
5. Renal Insufficiency
Bisoprolol is a beta-blocker primarily used to treat hypertension and coronary atherosclerotic heart disease. It helps control blood pressure and reduce myocardial oxygen consumption. However, after taking bisoprolol, renal blood flow may decrease, impairing kidney metabolic function and potentially leading to renal insufficiency.
Bisoprolol may cause certain side effects; therefore, it should be taken strictly under medical supervision. Patients must follow their doctor's instructions during treatment and undergo regular follow-up examinations.
