How are gallstones formed?
Dec 16, 2023
Source: Cainiu Health
Dr. Yang Ziqi
Introduction
Under normal circumstances, the formation of gallstones may be related to factors such as excess cholesterol, elevated bilirubin, changes in bile composition, impaired gallbladder function, and hypercholesterolemia. If gallstones are present, patients are advised to seek timely medical evaluation and treatment. Patients with gallstones may follow medical advice to use medications such as ursodeoxycholic acid tablets, indomethacin tablets, or Pishi Keli for treatment.
Under normal circumstances, gallstone formation may be related to factors such as excess cholesterol, elevated bilirubin, changes in bile composition, impaired gallbladder function, and hypercholesterolemia. Patients with gallstones are advised to seek timely medical evaluation and treatment. Specific analyses are as follows:
1. Excess Cholesterol
When cholesterol levels in the body are too high—exceeding the solubilizing capacity of bile—the excess cholesterol can crystallize within the gallbladder and eventually form stones.
2. Elevated Bilirubin
Bilirubin is a byproduct of red blood cell breakdown. In conditions such as liver cirrhosis, biliary tract infections, or certain blood disorders, increased bilirubin production may contribute to gallstone formation.
3. Changes in Bile Composition
The main components of bile include cholesterol, bile salts, and phospholipids. Alterations in the proportions of these components can change the physical and chemical properties of bile, potentially leading to gallstone formation.
4. Impaired Gallbladder Function
The gallbladder stores and concentrates bile. When gallbladder function declines, bile stasis may occur, increasing the risk of gallstone development.
5. Hypercholesterolemia
Cholesterol, lecithin, and bile salts in bile work together to maintain bile stability. In cases of hypercholesterolemia, cholesterol in bile becomes supersaturated, making it prone to crystallize and form stones.
Gallstone patients may follow medical advice to use medications such as ursodeoxycholic acid tablets, indomethacin tablets, or lithotripsy granules. During treatment, adequate rest is important; avoid excessive fatigue and maintain a regular daily routine.
