What are the clinical manifestations of respiratory depression caused by lorazepam tablets?

Generally, lorazepam tablets are a benzodiazepine medication primarily used to treat anxiety disorders, panic disorders, and anxiety associated with depressive symptoms. Clinical manifestations of respiratory depression caused by lorazepam may include difficulty breathing, apnea, reduced cough reflex, impaired consciousness, fatigue, and weakness. If any of these adverse symptoms occur after taking the medication, medical attention should be sought promptly. Specific details are as follows:

1. Difficulty breathing: This drug primarily enhances the activity of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain, producing sedative, hypnotic, anxiolytic, and muscle-relaxant effects. After administration, patients may experience breathlessness, shortness of breath, and slower-than-normal respiration, with a reduced respiratory rate below normal levels.

2. Apnea: Taking an excessive dose of the medication may lead to severe adverse reactions, including respiratory arrest, often accompanied by symptoms such as cyanosis of the lips.

3. Reduced cough reflex: Due to suppression of the respiratory center, the cough reflex may become weakened, impairing the clearance of airway secretions.

4. Impaired consciousness: Severe respiratory depression may result in confusion or even coma.

5. Fatigue and weakness: Significant respiratory depression can lead to insufficient oxygen supply, causing extreme fatigue and muscular weakness.

Lorazepam tablets have potential for addiction and dependence. Abrupt discontinuation after long-term use may trigger withdrawal symptoms such as anxiety, insomnia, and agitation. Therefore, the medication should be taken strictly as prescribed, without self-adjusting the dosage or stopping treatment abruptly. Additionally, activities requiring high concentration should be avoided during treatment to prevent accidents.