Can cyclophosphamide treat nephrotic syndrome?
Sep 20, 2024
Source: Cainiu Health
Dr. Yang Guang
Introduction
In general, cyclophosphamide can be used to treat nephrotic syndrome. Cyclophosphamide inhibits the proliferation of immune cells and reduces autoimmune responses, thereby alleviating inflammation and damage in the kidneys. This provides therapeutic effects for kidney injury caused by immune abnormalities in nephrotic syndrome. By suppressing inflammatory responses, cyclophosphamide can reduce urinary protein levels.
In general, cyclophosphamide can be used to treat nephrotic syndrome.
Cyclophosphamide is a cytotoxic agent and one of the broad-spectrum antineoplastic drugs. It has immunosuppressive effects by inhibiting DNA synthesis in cells, interfering with cell proliferation, reducing B lymphocyte function, and suppressing antibody production. In kidney diseases, it is commonly used to treat nephrotic syndrome, especially cases that are resistant to steroid therapy or prone to recurrence. By reducing antibody production from B cells and suppressing T cell-mediated nonspecific inflammatory responses, cyclophosphamide helps reduce or prevent the deposition of immune complexes in the glomeruli and interferes with cell proliferation, thereby exerting direct or indirect anti-inflammatory effects. When using cyclophosphamide, patients should strictly follow their doctor's instructions and pay attention to preventing potential side effects.
During an active phase of the disease, patients should rest in bed as much as possible to reduce the burden on the kidneys. At the same time, they should maintain appropriate in-bed or bedside activities to prevent the formation of limb thrombosis.
