What heart rate should lead to discontinuation of bisoprolol?

　　Bisoprolol is a beta-blocker, commonly available in capsule and tablet formulations. Generally, the decision to discontinue bisoprolol due to heart rate should follow a physician's guidance, but typically, a heart rate below 46 beats per minute may prompt a physician to recommend discontinuation. If there are any concerns, it is advisable to seek medical consultation in advance. A detailed explanation is as follows:

　　Usually, when the heart rate drops below 46 beats per minute, it is considered severe bradycardia, which may be a side effect caused by bisoprolol. In such cases, the medication should be discontinued or at least reduced under a physician's guidance to avoid further decreases in heart rate. A significantly low heart rate may lead to reduced cardiac output and even insufficient cerebral blood supply, posing a threat to the patient's health.

　　Prior to discontinuation, the physician will conduct a comprehensive evaluation of the patient's cardiovascular condition, such as whether hypertension is stable or whether arrhythmia has improved. If the condition is well-controlled and the patient does not exhibit other significant symptoms, discontinuation of the medication may be considered under medical supervision.

　　The medication should be tapered gradually rather than stopped abruptly to avoid disease recurrence or worsening. During the discontinuation process, vital signs such as heart rate and blood pressure should be closely monitored to ensure they remain within a safe range.