Can povidone-iodine be applied inside the mouth?
Generally, povidone-iodine can be applied inside the mouth, but it needs to be diluted first. If needed, it is recommended to consult a doctor. Detailed explanation is as follows:

Povidone-iodine has antibacterial and anti-inflammatory properties, effectively killing bacteria, fungi, and viruses, and can provide certain therapeutic effects for wounds, ulcers, and inflammatory conditions in the oral cavity. However, the mucous membrane inside the mouth is relatively delicate; applying undiluted povidone-iodine directly may irritate the oral mucosa, causing discomfort or pain. Therefore, diluting povidone-iodine before using it for oral disinfection can preserve its antibacterial effectiveness while reducing irritation to the oral mucosa.
Moreover, diluted povidone-iodine is more easily absorbed by the oral mucosa, thereby exerting better therapeutic effects. At the same time, diluted povidone-iodine is more acceptable to patients, decreasing adverse symptoms such as nausea and vomiting caused by irritation. Therefore, in clinical practice, doctors usually recommend patients use diluted povidone-iodine for disinfection.
For wounds or inflammation inside the mouth, in addition to disinfecting with povidone-iodine, it is also important to maintain oral hygiene and prevent food residue and bacterial growth.