Can povidone-iodine kill fungi?
Jan 22, 2025
Source: Cainiu Health
Dr. Liu Wenmin
Introduction
In general, povidone-iodine can kill fungi and should be used under medical guidance. The main component of povidone-iodine is an amorphous complex of iodine with a surfactant. This complex exerts its antimicrobial effect by releasing iodine molecules. The iodine molecules destroy the fungal cell wall and cell membrane, causing leakage of cellular contents, thereby achieving the bactericidal effect.
Generally, povidone-iodine can kill fungi. If needed for use, it should be applied under medical guidance. Detailed explanations are as follows:
The main component of povidone-iodine is an amorphous complex formed between iodine and a surfactant. This complex exerts an antibacterial effect by releasing iodine molecules. The iodine molecules can disrupt the fungal cell wall and cell membrane, causing leakage of cellular contents, thereby achieving a bactericidal effect. This bactericidal mechanism demonstrates strong antimicrobial activity against various microorganisms, including fungi.
Fungal cellular proteins are essential components of their cellular structure and function, playing a crucial role in maintaining fungal morphology and physiological activities. The iodine in povidone-iodine can chemically react with amino acid residues in fungal proteins, forming irreversible complexes, thereby altering the spatial structure and properties of the proteins, leading to protein denaturation. After protein denaturation, various biochemical reactions within the fungal cells cannot proceed normally, cellular physiological functions are lost, ultimately resulting in fungal death and achieving the bactericidal purpose.
Povidone-iodine should be avoided from contacting sensitive areas such as the eyes and oral mucous membranes to prevent irritation or injury. If allergic reactions such as rash, itching, or other symptoms occur during use, discontinue use immediately and consult a doctor for advice.
