What is the normal value for liver fibrosis?

Jan 24, 2025 Source: Cainiu Health

Dr. Gao Jun

Introduction

The assessment of normal values for liver fibrosis is primarily determined through a series of serological indicators and liver transient elastography. The normal value ranges for the four liver fibrosis markers are as follows: type III procollagen <18 ng/ml, type IV collagen 30-140 ng/ml, laminin 50-180 ng/ml, and hyaluronic acid <120 ng/ml.

Generally, the evaluation of normal values for liver fibrosis is primarily determined through a series of serological indicators and liver transient elastography measurements. The normal reference ranges for the four liver fibrosis markers are as follows: type III procollagen <18 ng/ml, type IV collagen 30-140 ng/ml, laminin 50-180 ng/ml, and hyaluronic acid <120 ng/ml. The normal range for liver transient elastography measurement is 2.8-7.4 kPa. Detailed explanations are as follows:

These indicators are clinically used as a basis for the preliminary assessment of liver fibrosis severity. When these indicators show abnormalities, it often suggests the possibility of liver fibrosis. For example, if one indicator is abnormal, it may indicate early-stage liver fibrosis; if three indicators are abnormal, it suggests more severe liver fibrosis; if all four indicators are abnormal, it may indicate advanced liver fibrosis, or even early cirrhosis may have developed. Liver transient elastography measures liver stiffness values using ultrasound technology, further assisting in assessing the degree of liver fibrosis.

It is important to maintain a healthy lifestyle, avoiding long-term heavy alcohol consumption, excessive obesity, and other unhealthy habits, as these can lead to chronic liver damage and subsequently trigger liver fibrosis.

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What is the hepatitis B virus

Hepatitis B virus (HBV) primarily invades the liver, leading to hepatitis B. If the condition continues to progress, it may develop into liver fibrosis or cirrhosis. The virus is mainly transmitted through blood, mother-to-child transmission, and sexual contact. After infection, symptoms such as fatigue and jaundice may occur. Therefore, timely antiviral treatment under a doctor's guidance is necessary after diagnosis.

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Can liver fibrosis be cured?

In general, whether liver fibrosis can be cured mainly depends on the patient's overall health condition and the stage of the clinical disease. If the patient is in good health and the condition is detected early, it is usually curable. However, if the patient's health condition is poor and the disease is detected at a later stage, it may be more difficult to treat. If any discomfort occurs, prompt medical attention is recommended.

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What are the causes of liver fibrosis?

In general, liver fibrosis may be related to long-term overexertion, unhealthy dietary habits, lack of exercise, fatty liver disease, alcoholic liver disease, and other factors. It is recommended to seek medical attention promptly, identify the underlying cause, and undergo symptomatic treatment under the guidance of a qualified physician. It is also advised to maintain healthy lifestyle habits and avoid consuming pickled foods, processed foods, and mold-contaminated food products to protect liver health.

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Which liver diseases are caused by alcohol consumption?

In general, liver diseases such as alcoholic fatty liver, alcoholic hepatitis, alcoholic liver fibrosis, alcoholic cirrhosis, and hepatocellular carcinoma may be caused by alcohol consumption. It is advisable to control alcohol intake and avoid long-term heavy drinking. Individuals who already have liver disease or impaired liver function should abstain from alcohol completely. Additionally, maintaining a balanced diet and avoiding excessive intake of fats and sugars is important.