What is the normal range for liver fibrosis indicators?

Jan 25, 2025 Source: Cainiu Health

Dr. Gao Jun

Introduction

The indicators of liver fibrosis include PCIII, IV-C, LN, HA, PLD, etc., with each having different normal value ranges and reflecting the condition and degree of liver fibrosis. If these indicators are elevated, it may suggest disease progression, requiring timely targeted treatment. At the same time, maintaining a regular作息 (作息 should be translated as "lifestyle routine" or "daily routine") and balanced diet is important to promote recovery. It is recommended to seek medical attention promptly and follow the doctor's advice for treatment.

Generally, indicators for liver fibrosis include Type III Procollagen (PCIII), Type IV Collagen (IV-C), Laminin (LN), Hyaluronidase (HA), and Prolyl Peptidase (PLD). These indicators vary in their numerical values. The normal value of PCIII is below 18 ng/mL, IV-C ranges from 30 to 140 ng/mL, LN ranges from 50 to 180 ng/mL, HA is below 120 ng/mL, and PLD is 1107 ± 19.5 u/L. Detailed analysis is as follows:

1. Type III Procollagen (PCIII)

Type III Procollagen (PCIII) can be used to analyze liver pathology and determine whether the condition is progressing. The normal range is typically below 18 ng/mL. Levels above this range indicate disease progression, which may develop into cirrhosis.

2. Type IV Collagen (IV-C)

Type IV Collagen (IV-C) reflects the degree of liver fibrosis. The normal range is between 30 and 140 ng/mL. Consistently elevated levels suggest a more severe condition that may progress to more serious diseases such as cirrhosis or liver cancer.

3. Laminin (LN)

Laminin (LN) can assess whether liver fibrosis affects esophageal varices. The normal range of laminin (LN) is between 50 and 180 ng/mL. Elevated levels indicate more severe disease with more pronounced esophageal varices.

4. Hyaluronidase (HA)

Hyaluronidase (HA) is commonly used to evaluate liver function and the extent of liver fibrosis or cirrhosis. The normal range is generally below 120 ng/mL. Higher values indicate more severe liver damage.

5. Prolyl Peptidase (PLD)

Prolyl Peptidase (PLD) indicates the extent of liver damage. The normal reference value is 1107 ± 19.5 u/L. An elevated level may indicate acute liver injury, which could progress to cirrhosis.

It should be noted that if the above indicators suggest abnormal liver function or progressive worsening of the condition, timely targeted treatment is required to avoid delays. During treatment, maintaining regular作息 and a balanced diet is important to promote recovery.

View All

What is the hepatitis B virus

Hepatitis B virus (HBV) primarily invades the liver, leading to hepatitis B. If the condition continues to progress, it may develop into liver fibrosis or cirrhosis. The virus is mainly transmitted through blood, mother-to-child transmission, and sexual contact. After infection, symptoms such as fatigue and jaundice may occur. Therefore, timely antiviral treatment under a doctor's guidance is necessary after diagnosis.

View Full Answer

Can liver fibrosis be cured?

In general, whether liver fibrosis can be cured mainly depends on the patient's overall health condition and the stage of the clinical disease. If the patient is in good health and the condition is detected early, it is usually curable. However, if the patient's health condition is poor and the disease is detected at a later stage, it may be more difficult to treat. If any discomfort occurs, prompt medical attention is recommended.

View Full Answer

What are the causes of liver fibrosis?

In general, liver fibrosis may be related to long-term overexertion, unhealthy dietary habits, lack of exercise, fatty liver disease, alcoholic liver disease, and other factors. It is recommended to seek medical attention promptly, identify the underlying cause, and undergo symptomatic treatment under the guidance of a qualified physician. It is also advised to maintain healthy lifestyle habits and avoid consuming pickled foods, processed foods, and mold-contaminated food products to protect liver health.

View Full Answer

Which liver diseases are caused by alcohol consumption?

In general, liver diseases such as alcoholic fatty liver, alcoholic hepatitis, alcoholic liver fibrosis, alcoholic cirrhosis, and hepatocellular carcinoma may be caused by alcohol consumption. It is advisable to control alcohol intake and avoid long-term heavy drinking. Individuals who already have liver disease or impaired liver function should abstain from alcohol completely. Additionally, maintaining a balanced diet and avoiding excessive intake of fats and sugars is important.