Is having a positive result for all three major hepatitis B markers contagious?

Generally, individuals with "Big Three Positive" (positive HBsAg, HBeAg, and anti-HBc) hepatitis B results are contagious. The detailed analysis is as follows:

"Big Three Positive" refers to a situation in the five-panel hepatitis B test where the hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), and hepatitis B core antibody (anti-HBc) are all positive. This typically indicates active viral replication and strong contagiousness. If a person with "Big Three Positive" has a high viral load in their blood, transmission can occur through transfusion of blood or blood products contaminated with the hepatitis B virus.

If a woman with "Big Three Positive" is pregnant, the virus can be transmitted to the newborn during pregnancy, childbirth, or close postnatal contact. Additionally, semen or vaginal secretions from individuals with "Big Three Positive" may contain the hepatitis B virus, and unprotected sexual contact with such individuals can lead to viral transmission.

To prevent the spread of hepatitis B virus, it is recommended to get vaccinated. Hepatitis B vaccination is an effective way to prevent infection. By receiving the hepatitis B vaccine, the immune system can be stimulated to produce antibodies, thereby reducing the risk of transmission. Avoid sharing personal items with hepatitis B patients to reduce the risk of blood exposure. Practice safe sex, such as using condoms, to lower the risk of sexual transmission. Maintain good personal hygiene, wash hands frequently, and avoid using unsterilized medical equipment and personal items.