What are the side effects of melatonin?
Feb 14, 2025
Source: Cainiu Health
Dr. Bai Hongmei
Introduction
Under normal circumstances, melatonin is a health supplement that regulates sleep. Possible side effects of melatonin may include weight gain, worsening insomnia, endocrine disorders, gastrointestinal discomfort, and nervous system damage. When using melatonin or other medications, it is important to follow the dosage and administration instructions provided by a healthcare professional or as indicated on the product label, avoiding excessive or long-term use.
Generally, melatonin is a health supplement that regulates sleep. Possible side effects of melatonin may include weight gain, worsened insomnia, endocrine disorders, gastrointestinal discomfort, and nervous system damage, among others. A detailed analysis is as follows:
1. Weight Gain
Melatonin may affect the body's metabolic processes, causing an imbalance between energy intake and expenditure, which can lead to weight gain. In some individuals, long-term melatonin use may result in hormonal imbalances, leading to increased body weight and abnormal fat accumulation.
2. Worsened Insomnia
Long-term melatonin use may interfere with the body's natural melatonin secretion rhythm, potentially causing symptoms such as vivid dreams, easy awakening, and low mood. For individuals who already suffer from insomnia, this may exacerbate their insomnia symptoms.
3. Endocrine Disorders
Melatonin participates in regulating the body's circadian rhythm and hormone secretion. Improper supplementation may disrupt the body's normal hormonal balance, causing endocrine disorders. Women may experience irregular menstrual cycles, while men may encounter decreased libido.
4. Gastrointestinal Discomfort
Melatonin may irritate the gastrointestinal mucosa and affect normal gastrointestinal function, potentially leading to discomfort such as stomach cramps. When taken in large doses, symptoms may worsen, causing abdominal pain, diarrhea, and other gastrointestinal reactions.
5. Nervous System Damage
Long-term melatonin use may affect the nervous system, causing symptoms such as headaches, drowsiness, and dizziness. Additionally, it may induce emotional disturbances, such as temporary feelings of depression or irritability.
During melatonin use, individuals should closely monitor their physical responses and seek medical attention promptly if any discomfort occurs. It is also important to follow medical advice or instructions on dosage and usage to avoid overdose or prolonged use.
