Can individuals with immunodeficiency receive the COVID-19 vaccine?

　　COVID-19 vaccines refer to vaccines against the novel coronavirus. Generally, whether individuals with immunodeficiency can receive the novel coronavirus vaccine mainly depends on the severity of their immunodeficiency. If the immunodeficiency is mild or moderate, vaccination is usually possible. However, if the immunodeficiency is severe, vaccination should not be administered. Detailed explanations are as follows:

　　For patients with mild or moderate primary or secondary immunodeficiency whose condition affects only a single immune component or is controlled through medication, vaccination may be considered after physician evaluation if the benefits outweigh the risks. The immune response generated by vaccination in these patients might be slightly weaker compared to healthy individuals, but it may still offer some degree of protection.

　　However, for individuals with severe immunodeficiency, their bodies may not effectively fight off infections. Therefore, after receiving the COVID-19 vaccine, they may fail to mount an adequate immune response and thus remain vulnerable to coronavirus infection. In such cases, vaccination might exacerbate symptoms of the immunodeficiency disorder and increase the risk of infection, which would be detrimental to disease control and recovery.

　　Individuals with immunodeficiency should enhance personal protective measures, avoid going to crowded places, minimize close contact with others, and maintain good hygiene practices to reduce the risk of contracting the coronavirus.