What are the side effects of Domperidone?
Mar 09, 2025
Source: Cainiu Health
Dr. Bai Hongmei
Introduction
The adverse effects of domperidone tablets include menstrual disorders, extrapyramidal reactions, arrhythmia, dry mouth, galactorrhea, and others. When taking domperidone tablets, do not increase the dosage or prolong the duration of treatment on your own. If you have pre-existing heart disease or are taking other medications that may affect cardiac function, be sure to inform your doctor in advance, so the doctor can comprehensively assess the medication-related risks.
Generally speaking, Motilium refers to domperidone tablets. The side effects of domperidone tablets include menstrual disorders, extrapyramidal reactions, arrhythmia, dry mouth, and galactorrhea. If this medication is needed, it is recommended to follow medical advice. Detailed analysis is as follows:
1. Menstrual Disorders
Domperidone tablets may affect hormone levels in the body, especially influencing the secretion of prolactin, thereby interfering with women's menstrual cycles. It may cause menstrual irregularities such as early or delayed menstruation, increased or decreased menstrual flow, affecting women's normal physiological cycles and physical health.
2. Extrapyramidal Reactions
Domperidone tablets may block dopamine receptors in the central nervous system, interfering with the normal functioning of dopaminergic neural pathways, thereby causing motor imbalance, such as limb tremors and muscle tone disorders.
3. Arrhythmia
Domperidone tablets may affect the electrophysiological activity of the heart, leading to prolonged QT interval on the electrocardiogram (ECG), increasing the risk of arrhythmias such as tachycardia and premature beats, which can be life-threatening in severe cases.
4. Dry Mouth
The medication may affect the secretory function of salivary glands, reducing saliva secretion and leaving the oral mucosa insufficiently moisturized, thus causing dry mouth sensations, leading to dry oral mucosa, altered taste, and possibly increasing the risk of oral infections.
5. Galactorrhea
Due to the drug's regulatory effect on prolactin, which disrupts the normal hormonal balance, domperidone tablets may cause galactorrhea in women, particularly those who are not lactating, meaning milk secretion from the breasts outside of lactation periods.
When taking domperidone tablets, do not increase the dosage or prolong the duration of use on your own. If you have heart disease or are taking other medications that may affect heart function, be sure to inform your doctor beforehand so that the doctor can comprehensively assess the medication risks.
