What are the efficacy and side effects of Compound Glycyrrhizin Tablets?

Generally, the effects of Compound Glycyrrhizin Tablets include anti-inflammatory action, anti-allergic effects, immune regulation, hepatoprotective effects, and antiviral activity. Side effects may include allergic reactions, gastrointestinal discomfort, headache, muscle pain, and menstrual irregularities. It is recommended to use this medication under medical supervision. Detailed explanations are as follows:

I. Effects of Compound Glycyrrhizin Tablets

1. Anti-inflammatory

Compound Glycyrrhizin Tablets can inhibit the activity of phospholipase A2, reducing the production of inflammatory mediators such as prostaglandins, thereby alleviating inflammatory responses. It is effective in relieving inflammatory conditions such as dermatitis and eczema.

2. Anti-allergic

This medication can stabilize mast cell membranes, preventing the release of allergic mediators such as histamine, thus alleviating allergic symptoms. It can be used in the treatment of allergic diseases such as allergic dermatitis and urticaria.

3. Immune regulation

Compound Glycyrrhizin Tablets regulate immune cells such as T cells and B cells, enhancing immune function and helping to improve the body's resistance to pathogens. It serves as an adjunct in treating immune-related diseases such as chronic liver disease.

4. Hepatoprotective effects

This medication inhibits triglyceride accumulation within liver cells, reducing hepatic steatosis. Additionally, it decreases the permeability of the hepatocyte membrane, reducing the release of intracellular enzymes, thus protecting liver cells and improving liver function. It is commonly used in the treatment of chronic hepatitis.

5. Antiviral

The medication has certain inhibitory effects on some viruses. For example, in the treatment of chronic hepatitis B, it can help suppress the replication of the hepatitis B virus and reduce liver damage caused by the virus.

II. Side Effects of Compound Glycyrrhizin Tablets

1. Allergic reactions

Some components of Compound Glycyrrhizin Tablets may be recognized by an individual's immune system as foreign antigens. Upon initial exposure, the immune system produces antibodies and sensitized lymphocytes. Upon re-exposure, antigen-antibody reactions activate immune cells, releasing histamine, which causes skin vasodilation and increased vascular permeability, leading to rashes. In severe cases, massive histamine release may cause systemic vasodilation and bronchoconstriction, resulting in anaphylactic shock.

2. Gastrointestinal discomfort

The drug directly irritates gastrointestinal mucosa, interfering with neural regulation and secretion of digestive fluids, affecting peristaltic rhythm and causing loss of appetite. It may also stimulate gastrointestinal receptors, causing nausea and vomiting, and potentially disrupting the intestinal microecology, leading to diarrhea and gastrointestinal dysfunction.

3. Headache

After entering the body, the medication affects cerebral vascular dilation and constriction functions, causing abnormal cerebral blood flow dynamics. Additionally, it disrupts the balance of central nervous system neurotransmitters, such as serotonin, thereby causing headaches.

4. Muscle pain

Compound Glycyrrhizin Tablets interfere with mitochondrial function in muscle cells, reducing energy production. They also alter intracellular calcium ion balance, affecting muscle contraction and relaxation, leading to muscle pain and weakness, which may severely affect limb mobility.

5. Menstrual irregularities

Female endocrine function relies on the hypothalamic-pituitary-gonadal axis regulation. Components of Compound Glycyrrhizin Tablets may interfere with hypothalamic or pituitary function, affecting the secretion of gonadotropin-releasing hormone, leading to irregular menstrual cycles and abnormal menstrual flow, thus affecting reproductive health.

During the use of Compound Glycyrrhizin Tablets, it is important to regularly monitor blood pressure, serum potassium, complete blood count, liver function, and other indicators to promptly detect potential side effects. Additionally, it is important to monitor your physical condition. If symptoms such as edema, rash, headache, or other discomforts occur, seek medical attention promptly and, under the guidance of a physician, determine whether to continue the medication or adjust the treatment plan.