Are there any side effects of melatonin vitamin B6 tablets?
Jun 25, 2025
Source: Cainiu Health
Dr. Yang Ziqi
Introduction
Melatonin with vitamin B6 tablets may cause side effects such as gastrointestinal reactions, allergic reactions, neurological symptoms, sexual dysfunction, and endocrine disruption. It is recommended to strictly follow the instructions or medical advice, avoid long-term and high-dose use, and consult a physician in advance for special populations, such as pregnant women, lactating women, patients with autoimmune diseases, and individuals currently taking medications, to reduce the risk of adverse reactions.
Generally, melatonin vitamin B6 tablets may have side effects such as gastrointestinal reactions, allergic reactions, neurological symptoms, sexual dysfunction, and endocrine disruption. The details are as follows:
1. Gastrointestinal Reactions
This is one of the more common side effects of melatonin vitamin B6 tablets, which may manifest as gastrointestinal discomfort symptoms such as nausea, vomiting, diarrhea, or constipation. These reactions are usually mild and symptoms typically subside gradually after discontinuation or dosage adjustment.
2. Allergic Reactions
A small number of people may experience allergic reactions to melatonin or vitamin B6, presenting symptoms such as itching, rash, or swelling. If allergic reactions occur, discontinue use immediately and seek medical attention.
3. Neurological Symptoms
Long-term or excessive use of melatonin vitamin B6 tablets may lead to neurological symptoms such as dizziness, tinnitus, hearing loss, or even arrhythmia. These symptoms may be serious and prompt medical attention along with consultation with a physician is necessary.
4. Sexual Dysfunction
Excessive intake of melatonin vitamin B6 tablets by young people may lead to adverse effects such as sexual dysfunction and reduced libido. Therefore, young people should use such supplements cautiously and follow medical advice.
5. Endocrine Disruption
Long-term use may affect the body's own melatonin secretion function, leading to reduced endogenous melatonin synthesis. Additionally, melatonin has a regulatory effect on the hypothalamic-pituitary axis and may indirectly influence the secretion balance of sex hormones such as estrogen and testosterone.
The side effects of melatonin vitamin B6 tablets are mostly related to dosage, individual sensitivity, or inappropriate combination use. Short-term use at normal doses is relatively safe. It is recommended to strictly follow the instructions or physician's advice, avoid long-term high-dose use, and consult a doctor in advance for special populations such as pregnant women, lactating women, patients with autoimmune diseases, and individuals currently taking other medications, in order to reduce the risk of adverse reactions.
