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What are the risks and side effects of wrinkle-relaxing injections?

Jun 26, 2025 Source: Cainiu Health
Dr. Yang Ziqi
Introduction
In general, wrinkle-relaxing injections are a method of reducing wrinkles by injecting large-molecule fillers, collagen substances, cell-active agents that promote skin regeneration, or even stem cells into the wrinkled areas. Risks and side effects of wrinkle-relaxing injections include facial expression stiffness, eye dysfunction, mouth deviation, difficulty swallowing, and skin necrosis.

Generally, wrinkle-relaxing injections are non-surgical cosmetic procedures that involve injecting biological agents or fillers to correct facial wrinkles. The typical reference price for wrinkle-relaxing injections ranges from 1000 to 3000 yuan per session, with visible improvements usually seen within 3 to 7 days. Potential risks and side effects of wrinkle-relaxing injections include facial expression stiffness, ocular dysfunction, mouth asymmetry, difficulty swallowing, and skin necrosis. A detailed analysis is as follows:

1. Facial Expression Stiffness

If the dosage or injection site of the wrinkle-relaxing injection is inappropriate, it may affect the normal movement of facial muscles, leading to unnatural and stiff facial expressions, such as an inability to frown or smile normally.

2. Ocular Dysfunction

When administering wrinkle-relaxing injections around the eyes, if the injected agent spreads to the extraocular muscles, it may cause ptosis (drooping eyelid), eye muscle paralysis, and other issues, resulting in difficulty fully opening the eyes, double vision, and impaired visual function.

3. Mouth Asymmetry

When administering wrinkle-relaxing injections on the face, particularly for perioral wrinkles, improper technique may lead to an imbalance in the strength of the muscles around the mouth, causing the corners of the mouth to become uneven. This not only affects facial aesthetics but may also interfere with normal speech and eating.

4. Difficulty Swallowing

When administering wrinkle-relaxing injections in the neck or facial areas near the throat, the injected agent may affect the function of throat muscles, leading to muscle weakness and causing difficulty swallowing. In severe cases, this may affect nutrient intake and overall health.

5. Skin Necrosis

If hyaluronic acid or other filler-type wrinkle-relaxing injections are accidentally injected into a blood vessel, vascular occlusion may occur, resulting in ischemia and subsequent necrosis of the local skin tissue. This can leave permanent skin scars and severely impact skin appearance.

After receiving wrinkle-relaxing injections, it is essential to follow the doctor's instructions for post-treatment care strictly. Avoid applying heat or massaging the injection sites, as this may cause the agent to spread or interfere with its intended effect. Additionally, maintain cleanliness and dryness at the injection site to prevent infection.

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How many days after receiving wrinkle-relaxing injections will the effects become noticeable?
In general, anti-wrinkle injections refer to products that are administered by injection into the skin to stimulate collagen regeneration, thereby restoring the skin's youthful appearance. These injections can effectively address facial skin aging issues caused by various factors, such as wrinkles and skin depressions. The usual cost ranges from 3000 to 6000 per session, and noticeable results can typically be seen within 3 to 15 days after the procedure.
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How long does it take for wrinkles to return to normal after Botox injections?
Under normal circumstances, it may take about 1-2 weeks to recover naturally after wrinkle-relaxing injections. Wrinkle-relaxing injections work by precisely administering specific biologics or fillers, such as botulinum toxin, into targeted facial muscles or skin tissues. Botulinum toxin blocks nerve impulses between nerves and muscles, causing over-contracted muscles to relax, thereby reducing the appearance of wrinkles.
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Are there any side effects to frequently receiving anti-wrinkle injections?
Under normal circumstances, frequent administration of wrinkle-relaxing injections may lead to enhanced dependency, accelerated skin aging, facial stiffness, local pain, allergic reactions, and other side effects. Maintaining adequate sleep, a balanced diet, and moderate exercise can help preserve overall health, thereby slowing the rate of skin aging. In addition, avoiding不良 habits such as smoking and alcohol consumption also contributes to maintaining healthy and youthful skin.
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Do wrinkle-reducing treatments work on true wrinkles?
Anti-wrinkle injections primarily improve skin condition through the injection of fillers such as hyaluronic acid and collagen to repair and plump the skin. They generally work well for mild true wrinkles, can stimulate collagen regeneration, and improve the depth of wrinkles. However, for severe true wrinkles, the effects of anti-wrinkle injections are often unsatisfactory and may even cause uneven skin texture, affecting postoperative recovery.
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Can wrinkle-relaxing injections and hyaluronic acid injections be administered at the same time?
In general, wrinkle-relaxing injections and hyaluronic acid (water-light) injections can be administered simultaneously. The primary function of water-light injections is to hydrate and moisturize the skin by delivering solutions containing hyaluronic acid, vitamins, amino acids, and other nutrients into the dermal layer. Wrinkle-relaxing injections, on the other hand, are primarily used to treat dynamic wrinkles; their active ingredients block nerve signals to the muscles, causing muscle atrophy and thereby reducing wrinkles.
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How many injections are needed for wrinkle-reducing injections?
Anti-wrinkle injections may require 1 to 3 sessions, depending specifically on the severity of the wrinkles. One injection is recommended for mild wrinkles, two injections for moderate wrinkles, and three injections for severe wrinkles. It is advised to visit a reputable hospital and undergo the procedure under the guidance of a qualified physician to ensure safety and effectiveness. Avoid getting the injected areas wet for 24 hours after the procedure.
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Does applying heat after receiving wrinkle-relaxing injections accelerate metabolism?
Under normal circumstances, applying heat after receiving wrinkle-relaxing injections can accelerate metabolism. The main component of wrinkle-relaxing injections is botulinum toxin. Heat application can enhance local blood circulation and metabolic rate, promoting quicker absorption of the active ingredients in the injected solution and also helping to relieve facial muscle stiffness. If improper technique or suboptimal results occur early after injection, heat therapy may be used for correction.
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Is it normal to develop a few lumps in the area where anti-wrinkle injections were administered?
Whether localized swelling after injection of wrinkle-relaxing injections is normal depends on the specific symptoms. If the symptoms are mild and short-lived, it may be a normal reaction, usually related to drug irritation, and typically resolves within about 24 hours. If symptoms persist and are accompanied by pain, itching, redness, or swelling, it is more likely abnormal, commonly associated with drug allergy, infection, or other factors.
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