What does central hypothyroidism mean?
Jul 08, 2025
Source: Cainiu Health
Dr. Yang Chuanjia
Introduction
In general, central hypothyroidism refers to a condition characterized by insufficient secretion of thyroid hormones due to inadequate production of thyroid-stimulating hormone (TSH), resulting from dysfunction of the hypothalamus or pituitary gland. Patients with central hypothyroidism should strictly follow their physician's recommendations for treatment and lifestyle modifications during the course of therapy.
In general, central hypothyroidism refers to central thyroid dysfunction caused by inadequate secretion of thyroid-stimulating hormone (TSH) due to hypothalamic or pituitary dysfunction, which subsequently leads to reduced synthesis and secretion of thyroid hormones. A detailed explanation is as follows:
Central hypothyroidism arises due to lesions in the hypothalamus or pituitary gland. The hypothalamus secretes thyrotropin-releasing hormone (TRH), which acts on the pituitary gland to stimulate the secretion of TSH. In turn, TSH regulates the synthesis and secretion of thyroid hormones by the thyroid gland. When the hypothalamus or pituitary gland is affected by conditions such as tumors, inflammation, or injury, the normal secretion of TSH is impaired. Consequently, the thyroid gland receives insufficient TSH stimulation, leading to a decrease in its ability to synthesize and secrete thyroid hormones. This results in a series of symptoms associated with hypothyroidism, including reduced metabolic rate, cold intolerance, fatigue, somnolence, and weight gain.
Patients with central hypothyroidism should strictly follow medical advice regarding treatment and lifestyle adjustments. Additionally, maintaining a positive mindset and undergoing regular follow-up examinations are essential for timely detection and management of any issues.
