What are the differences between Itopride Hydrochloride Tablets and Mosapride Citrate Tablets?

Jul 11, 2025 Source: Cainiu Health

Dr. Shen Yonghua

Introduction

The differences between Itopride Hydrochloride Tablets and Mosapride Citrate Tablets generally include mechanisms of action and indications. Itopride Hydrochloride Tablets enhance gastrointestinal motility by promoting the release of acetylcholine and simultaneously inhibiting its degradation; Mosapride Citrate Tablets mainly stimulate cholinergic interneurons and myenteric plexus receptors in the gastrointestinal tract, promoting gastrointestinal peristalsis. The two medications have different mechanisms of action.

　　The differences between Itopride Hydrochloride Tablets and Mosapride Citrate Tablets generally include mechanisms of action, indications, sites of action, metabolic pathways, and manifestations of adverse reactions. A detailed analysis is as follows:

　　1. Mechanism of Action: Itopride Hydrochloride Tablets enhance gastrointestinal motility by promoting the release of acetylcholine and simultaneously inhibiting its degradation; Mosapride Citrate Tablets mainly act on cholinergic interneurons and the myenteric plexus receptors in the gastrointestinal tract to promote gastrointestinal peristalsis. Therefore, their mechanisms of action differ.

　　2. Indications: Itopride Hydrochloride Tablets are indicated for upper abdominal discomfort, postprandial fullness, loss of appetite, and other symptoms caused by functional dyspepsia; Mosapride Citrate Tablets can not only improve symptoms related to dyspepsia but also treat gastrointestinal motility disorders caused by gastroesophageal reflux disease and diabetic gastroparesis.

　　3. Site of Action: Itopride Hydrochloride Tablets have a more pronounced prokinetic effect on the stomach and duodenum; Mosapride Citrate Tablets have a broader range of action and can affect the entire gastrointestinal tract, including the small and large intestines, promoting overall intestinal peristalsis.

　　4. Metabolic Pathway: Itopride Hydrochloride Tablets are primarily metabolized in the liver via cytochrome enzymes; Mosapride Citrate Tablets are metabolized in the liver, and the metabolites are mainly excreted via urine and feces, indicating differences in their metabolic pathways.

　　5. Adverse Reaction Manifestations: Itopride Hydrochloride Tablets may cause dry mouth, diarrhea, headache, and other adverse reactions; common adverse reactions of Mosapride Citrate Tablets include diarrhea, abdominal pain, dizziness, etc. There are differences in specific manifestations and incidence rates of adverse reactions between the two drugs.

　　Both medications should be used under the guidance of a physician. Self-substitution or dose adjustment is not recommended. If discomfort occurs during medication, promptly inform your doctor, who will determine whether to continue the medication or adjust the treatment plan.

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